Electrophysiological breakthroughs from the left atrium to the pulmonary veins.

Gender Differences in the Electrophysiological Characteristics of Pulmonary Veins and Left Atrium and Their Clinical Implication in Atrial Fibrillation Running title: Tsai et al.; Gender differences in AF

Electrophysiological effects of the antiarrhythmic drug bepridil on the guinea-pig pulmonary vein myocardium.

We compared effects of the antiarrhythmic drug bepridil on the electrophysiological parameters in the isolated pulmonary vein preparation from guinea pigs with those in the left atrium. Three pairs of bipolar electrodes were attached to the left atrium, pulmonary vein and junctional region of left atrium and pulmonary vein to measure intra-atrial and intra-pulmonary vein conduction velocity and...

Electrophysiological Findings in Adolescents With Atrial Fibrillation Who Have Structurally Normal Hearts

Background—Atrial fibrillation (AF) is uncommon in children, and its mechanisms are unknown. This study describes the electrophysiological findings in children and adolescents with AF and the outcome of catheter ablation. Methods and Results—Nine adolescents with symptomatic, lone AF who failed antiarrhythmic drug therapy were evaluated. All patients had ECG-documented AF and underwent invasive...

Letter regarding article by Nanthakumar et al, "Electrophysiological findings in adolescents with atrial fibrillation who have structurally normal hearts".

BACKGROUND Atrial fibrillation (AF) is uncommon in children, and its mechanisms are unknown. This study describes the electrophysiological findings in children and adolescents with AF and the outcome of catheter ablation. METHODS AND RESULTS Nine adolescents with symptomatic, lone AF who failed antiarrhythmic drug therapy were evaluated. All patients had ECG-documented AF and underwent invasi...

Mounting evidence that fibrosis generates a major mechanism for atrial fibrillation.

It is widely known that atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with the problem magnified by the clinical sequelae; eg, thromboembolic events. It is pertinent that the incidence of AF is expected to increase in the future,1 especially in aging patients. Thus, finding preventive measures for this arrhythmia has become an increasingly important goal. In addition...